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Src Phosphorylation of Alix/AIP1 Modulates Its Interaction with Binding Partners and Antagonizes Its Activities

Alix/AIP1 is an adaptor protein involved in regulating the function of receptor and cytoskeleton-associated tyrosine kinases. Here, we investigated its interaction with and regulation by Src. Tyr(319) of Alix bound the isolated Src homology-2 (SH2) domain and was necessary for interaction with intac...

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Detalhes bibliográficos
Main Authors: Schmidt, Mirko H. H., Dikic, Ivan, Bögler, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1180480/
https://ncbi.nlm.nih.gov/pubmed/15557335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M409839200
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