Pharmacological Inhibition of NLRP3 Inflammasome Attenuates Myocardial Ischemia/Reperfusion Injury by Activation of RISK and Mitochondrial Pathways

Although the nucleotide-binding oligomerization domain- (NOD-) like receptor pyrin domain containing 3 (NLRP3) inflammasome has been recently detected in the heart, its role in cardiac ischemia/reperfusion (IR) is still controversial. Here, we investigate whether a pharmacological modulation of NLRP...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Mastrocola, Raffaella, Penna, Claudia, Tullio, Francesca, Femminò, Saveria, Nigro, Debora, Chiazza, Fausto, Serpe, Loredana, Collotta, Debora, Alloatti, Giuseppe, Cocco, Mattia, Bertinaria, Massimo, Pagliaro, Pasquale, Aragno, Manuela, Collino, Massimo
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5178375/
https://ncbi.nlm.nih.gov/pubmed/28053692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/5271251
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