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Glutathione S-transferase mediates an ageing response to mitochondrial dysfunction
To understand primary mitochondrial disease, we utilized a complex I-deficient Caenorhabditis elegans mutant, gas-1. These animals strongly upregulate the expression of gst-14 (encoding a glutathione S-transferase). Knockdown of gst-14 dramatically extends the lifespan of gas-1 and increases hydroxy...
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| Publicado no: | Mech Ageing Dev |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5178136/ https://ncbi.nlm.nih.gov/pubmed/26704446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2015.12.001 |
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