Tyrosine Hydroxylase Binding to Phospholipid Membranes Prompts Its Amyloid Aggregation and Compromises Bilayer Integrity

Tyrosine hydroxylase (TH), a rate-limiting enzyme in the synthesis of catecholamine neurotransmitters and hormones, binds to negatively charged phospholipid membranes. Binding to both large and giant unilamellar vesicles causes membrane permeabilization, as observed by efflux and influx of fluoresce...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Baumann, Anne, Jorge-Finnigan, Ana, Jung-KC, Kunwar, Sauter, Alexander, Horvath, Istvan, Morozova-Roche, Ludmilla A., Martinez, Aurora
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5177901/
https://ncbi.nlm.nih.gov/pubmed/28004763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39488
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