Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules

Tyrosine hydroxylase (TH) catalyzes the conversion of l-tyrosine into l-DOPA, which is the rate-limiting step in the synthesis of catecholamines, such as dopamine, in dopaminergergic neurons. Low dopamine levels and death of the dopaminergic neurons are hallmarks of Parkinson's disease (PD), wh...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Jorge-Finnigan, Ana, Kleppe, Rune, Jung-KC, Kunwar, Ying, Ming, Marie, Michael, Rios-Mondragon, Ivan, Salvatore, Michael F., Saraste, Jaakko, Martinez, Aurora
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Neurobiology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572922/
https://ncbi.nlm.nih.gov/pubmed/28637871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.762344
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