Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules

Tyrosine hydroxylase (TH) catalyzes the conversion of l-tyrosine into l-DOPA, which is the rate-limiting step in the synthesis of catecholamines, such as dopamine, in dopaminergergic neurons. Low dopamine levels and death of the dopaminergic neurons are hallmarks of Parkinson's disease (PD), wh...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Jorge-Finnigan, Ana, Kleppe, Rune, Jung-KC, Kunwar, Ying, Ming, Marie, Michael, Rios-Mondragon, Ivan, Salvatore, Michael F., Saraste, Jaakko, Martinez, Aurora
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572922/
https://ncbi.nlm.nih.gov/pubmed/28637871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.762344
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados