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Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules
Tyrosine hydroxylase (TH) catalyzes the conversion of l-tyrosine into l-DOPA, which is the rate-limiting step in the synthesis of catecholamines, such as dopamine, in dopaminergergic neurons. Low dopamine levels and death of the dopaminergic neurons are hallmarks of Parkinson's disease (PD), wh...
Guardat en:
| Publicat a: | J Biol Chem |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5572922/ https://ncbi.nlm.nih.gov/pubmed/28637871 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.762344 |
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