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Stable preparations of tyrosine hydroxylase provide the solution structure of the full-length enzyme
Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of catecholamine neurotransmitters. TH is a highly complex enzyme at mechanistic, structural, and regulatory levels, and the preparation of kinetically and conformationally stable enzyme for structural characterization ha...
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| Pubblicato in: | Sci Rep |
|---|---|
| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4961952/ https://ncbi.nlm.nih.gov/pubmed/27462005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30390 |
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