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Linking genomic reorganization to tumor initiation via the giant cell cycle

To investigate the mechanisms underlying our recent paradoxical finding that mitotically incapacitated and genomically unstable polyploid giant cancer cells (PGCCs) are capable of tumor initiation, we labeled ovarian cancer cells with α-tubulin fused to green fluorescent protein, histone-2B fused to...

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Detalhes bibliográficos
Publicado no:Oncogenesis
Main Authors: Niu, N, Zhang, J, Zhang, N, Mercado-Uribe, I, Tao, F, Han, Z, Pathak, S, Multani, A S, Kuang, J, Yao, J, Bast, R C, Sood, A K, Hung, M-C, Liu, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5177773/
https://ncbi.nlm.nih.gov/pubmed/27991913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2016.75
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