Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2

Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by using the pluripotency factors Oct4, Sox2, Klf4 and c-Myc (together referred to as OSKM)(1). iPSC reprogramming erases somatic epigenetic signatures—as typified by DNA methylation or histone modification at silent pluri...

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Foilsithe in:Nature
Main Authors: Doege, Claudia A., Inoue, Keiichi, Yamashita, Toru, Rhee, David B., Travis, Skylar, Fujita, Ryousuke, Guarnieri, Paolo, Bhagat, Govind, Vanti, William B., Shih, Alan, Levine, Ross L., Nik, Sara, Chen, Emily I., Abeliovich, Asa
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5176099/
https://ncbi.nlm.nih.gov/pubmed/22902501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11333
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