Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2

Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by using the pluripotency factors Oct4, Sox2, Klf4 and c-Myc (together referred to as OSKM)(1). iPSC reprogramming erases somatic epigenetic signatures—as typified by DNA methylation or histone modification at silent pluri...

Deskribapen osoa

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Xehetasun bibliografikoak
Argitaratua izan da:Nature
Egile Nagusiak: Doege, Claudia A., Inoue, Keiichi, Yamashita, Toru, Rhee, David B., Travis, Skylar, Fujita, Ryousuke, Guarnieri, Paolo, Bhagat, Govind, Vanti, William B., Shih, Alan, Levine, Ross L., Nik, Sara, Chen, Emily I., Abeliovich, Asa
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5176099/
https://ncbi.nlm.nih.gov/pubmed/22902501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11333
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