H2B ubiquitination regulates meiotic recombination by promoting chromatin relaxation

Meiotic recombination is essential for fertility in most sexually reproducing species, but the molecular mechanisms underlying this process remain poorly understood in mammals. Here, we show that RNF20-mediated H2B ubiquitination is required for meiotic recombination. A germ cell-specific knockout o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Xu, Zhiliang, Song, Zhenhua, Li, Guoping, Tu, Huayu, Liu, Weixiao, Liu, Yujiao, Wang, Pan, Wang, Yuanting, Cui, Xiuhong, Liu, Chao, Shang, Yongliang, de Rooij, Dirk G., Gao, Fei, Li, Wei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2016
Pynciau:
Gene regulation, Chromatin and Epigenetics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5175339/
https://ncbi.nlm.nih.gov/pubmed/27431324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw652
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