H2B ubiquitination regulates meiotic recombination by promoting chromatin relaxation

Meiotic recombination is essential for fertility in most sexually reproducing species, but the molecular mechanisms underlying this process remain poorly understood in mammals. Here, we show that RNF20-mediated H2B ubiquitination is required for meiotic recombination. A germ cell-specific knockout o...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Xu, Zhiliang, Song, Zhenhua, Li, Guoping, Tu, Huayu, Liu, Weixiao, Liu, Yujiao, Wang, Pan, Wang, Yuanting, Cui, Xiuhong, Liu, Chao, Shang, Yongliang, de Rooij, Dirk G., Gao, Fei, Li, Wei
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
Matèries:
Gene regulation, Chromatin and Epigenetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5175339/
https://ncbi.nlm.nih.gov/pubmed/27431324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw652
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