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Requirement of yeast Rad1–Rad10 nuclease for the removal of 3′-blocked termini from DNA strand breaks induced by reactive oxygen species
The Rad1-Rad10 nuclease of yeast and its human counterpart ERCC1-XPF are indispensable for nucleotide excision repair, where they act by cleaving the damaged DNA strand on the 5′-side of the lesion. Intriguingly, the ERCC1- and XPF-deficient mice show a severe postnatal growth defect and they die at...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC517521/ https://ncbi.nlm.nih.gov/pubmed/15371342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1232804 |
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