Astragaloside IV Attenuates Podocyte Apoptosis Mediated by Endoplasmic Reticulum Stress through Upregulating Sarco/Endoplasmic Reticulum Ca(2+)-ATPase 2 Expression in Diabetic Nephropathy

Sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) plays a central role in the pathogenesis of diabetes. This protein has been recognized as a potential target for diabetic therapy. In this study, we identified astragaloside IV (AS-IV) as a potent modulator of SERCA inhibiting renal injury in diabeti...

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Publicat a:Front Pharmacol
Autors principals: Guo, Hengjiang, Cao, Aili, Chu, Shuang, Wang, Yi, Zang, Yingjun, Mao, Xiaodong, Wang, Hao, Wang, Yunman, Liu, Cheng, Zhang, Xuemei, Peng, Wen
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2016
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5174081/
https://ncbi.nlm.nih.gov/pubmed/28066247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00500
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