טוען...
The use of aminoglycoside derivatives to study the mechanism of aminoglycoside 6′-N-acetyltransferase and the role of 6′-NH(2) in antibacterial activity
Aminoglycoside antibiotics act by binding to 16S rRNA. Resistance to these antibiotics occurs via drug modifications by enzymes such as aminoglycoside 6′-N-acetyltransferases (AAC(6′)s). We report here the regioselective and efficient synthesis of N-6′-acylated aminoglycosides and their use as probe...
שמור ב:
| הוצא לאור ב: | Bioorg Med Chem |
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| Main Authors: | , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2007
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5173354/ https://ncbi.nlm.nih.gov/pubmed/17317190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.02.009 |
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