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Synthesis of a phosphonate-linked aminoglycoside-coenzyme A bisubstrate and use in mechanistic studies of an enzyme involved in aminoglycoside resistance

Aminoglycoside N-6′-acetyltransferases (AAC(6′)s) are important determinants of antibiotic resistance. A good mechanistic understanding of these enzymes is essential to overcome aminoglycoside resistance. We have previously reported the synthesis of amide-linked and sulfonamide-linked aminoglycoside...

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Bibliografiske detaljer
Main Authors: Gao, Feng, Yan, Xuxu, Auclair, Karine
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084187/
https://ncbi.nlm.nih.gov/pubmed/19152351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.200802172
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