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Synthesis of a phosphonate-linked aminoglycoside-coenzyme A bisubstrate and use in mechanistic studies of an enzyme involved in aminoglycoside resistance
Aminoglycoside N-6′-acetyltransferases (AAC(6′)s) are important determinants of antibiotic resistance. A good mechanistic understanding of these enzymes is essential to overcome aminoglycoside resistance. We have previously reported the synthesis of amide-linked and sulfonamide-linked aminoglycoside...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3084187/ https://ncbi.nlm.nih.gov/pubmed/19152351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.200802172 |
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