PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells

Dysfunctional clock signaling is observed in a variety of pathological conditions. Many members of the clock gene family are upregulated in tumor cells. Here, we explored the consequences of a commonly disrupted signaling pathway in head and neck cancer on the regulation of circadian clock genes. PT...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Matsumoto, Camila S., Almeida, Luciana O., Guimarães, Douglas M., Martins, Manoela D., Papagerakis, Petros, Papagerakis, Silvana, Leopoldino, Andreia M., Castilho, Rogerio M., Squarize, Cristiane H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173143/
https://ncbi.nlm.nih.gov/pubmed/27285754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9877
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