PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells

Dysfunctional clock signaling is observed in a variety of pathological conditions. Many members of the clock gene family are upregulated in tumor cells. Here, we explored the consequences of a commonly disrupted signaling pathway in head and neck cancer on the regulation of circadian clock genes. PT...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Oncotarget
Hlavní autoři: Matsumoto, Camila S., Almeida, Luciana O., Guimarães, Douglas M., Martins, Manoela D., Papagerakis, Petros, Papagerakis, Silvana, Leopoldino, Andreia M., Castilho, Rogerio M., Squarize, Cristiane H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173143/
https://ncbi.nlm.nih.gov/pubmed/27285754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9877
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky