Functional TRAIL receptors in monocytes and tumor-associated macrophages: A possible targeting pathway in the tumor microenvironment

Despite the accepted dogma that TRAIL kills only tumor cells and spares normal ones, we show in this study that mononuclear phagocytes are susceptible to recombinant TRAIL via caspase-dependent apoptosis. Human resting monocytes and in vitro-differentiated macrophages expressed substantial levels of...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Liguori, Manuela, Buracchi, Chiara, Pasqualini, Fabio, Bergomas, Francesca, Pesce, Samantha, Sironi, Marina, Grizzi, Fabio, Mantovani, Alberto, Belgiovine, Cristina, Allavena, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173086/
https://ncbi.nlm.nih.gov/pubmed/27191500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9340
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