Functional TRAIL receptors in monocytes and tumor-associated macrophages: A possible targeting pathway in the tumor microenvironment

Despite the accepted dogma that TRAIL kills only tumor cells and spares normal ones, we show in this study that mononuclear phagocytes are susceptible to recombinant TRAIL via caspase-dependent apoptosis. Human resting monocytes and in vitro-differentiated macrophages expressed substantial levels of...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Liguori, Manuela, Buracchi, Chiara, Pasqualini, Fabio, Bergomas, Francesca, Pesce, Samantha, Sironi, Marina, Grizzi, Fabio, Mantovani, Alberto, Belgiovine, Cristina, Allavena, Paola
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173086/
https://ncbi.nlm.nih.gov/pubmed/27191500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9340
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