Proteinase-activated receptor 2 promotes TGF-β-dependent cell motility in pancreatic cancer cells by sustaining expression of the TGF-β type I receptor ALK5

Pancreatic ductal adenocarcinoma (PDAC) is characterized by high expression of transforming growth factor (TGF)-β and the G protein-coupled receptor proteinase-activated receptor 2 (PAR2), the latter of which functions as a cell-surface sensor for serine proteinases asscociated with the tumour micro...

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Udgivet i:Oncotarget
Main Authors: Zeeh, Franziska, Witte, David, Gädeken, Thomas, Rauch, Bernhard H., Grage-Griebenow, Evelin, Leinung, Nadja, Fromm, Sofie Joline, Stölting, Stephanie, Mihara, Koichiro, Kaufmann, Roland, Settmacher, Utz, Lehnert, Hendrik, Hollenberg, Morley D., Ungefroren, Hendrik
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173045/
https://ncbi.nlm.nih.gov/pubmed/27248167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9600
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