Sialic acid removal from dendritic cells improves antigen cross-presentation and boosts anti-tumor immune responses

Dendritic cells (DCs) hold promise for anti-cancer immunotherapy. However, clinically, their efficiency is limited and novel strategies to improve DC-mediated anti-tumor responses are needed. Human DCs display high content of sialic acids, which inhibits their maturation and co-stimulation capacity....

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Silva, Mariana, Silva, Zélia, Marques, Graça, Ferro, Tiago, Gonçalves, Márcia, Monteiro, Mauro, van Vliet, Sandra J., Mohr, Elodie, Lino, Andreia C., Fernandes, Alexandra R., Lima, Flávia A., van Kooyk, Yvette, Matos, Teresa, Tadokoro, Carlos E., Videira, Paula A.
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2016
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173042/
https://ncbi.nlm.nih.gov/pubmed/27203391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9419
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