Perturbation of neddylation-dependent NF-κB responses in the intestinal epithelium drives apoptosis and inhibits resolution of mucosal inflammation

Recent work has revealed a central role for neddylation (the conjugation of a Nedd8 moiety to Cullin proteins) in the fine-tuning of the NF-κB response (via Cullin-1). In the present study, we investigated the contribution of Cullin-1 neddylation and NF-κB signaling to mucosal inflammatory responses...

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Udgivet i:Mol Biol Cell
Main Authors: Ehrentraut, Stefan F., Curtis, Valerie F., Wang, Ruth X., Saeedi, Bejan J., Ehrentraut, Heidi, Onyiah, Joseph C., Kelly, Caleb J., Campbell, Eric L., Glover, Louise E., Kominsky, Douglas J., Colgan, Sean P.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2016
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5170552/
https://ncbi.nlm.nih.gov/pubmed/27682585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-05-0273
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