Directed differentiation of human iPSC into insulin producing cells is improved by induced expression of PDX1 and NKX6.1 factors in IPC progenitors

BACKGROUND: Induced pluripotent stem cells (iPSC) possess an enormous potential as both, scientific and therapeutic tools. Their application in the regenerative medicine provides new treatment opportunities for numerous diseases, including type 1 diabetes. In this work we aimed to derive insulin pro...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Transl Med
Prif Awduron: Walczak, Maciej P., Drozd, Anna M., Stoczynska-Fidelus, Ewelina, Rieske, Piotr, Grzela, Dawid P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2016
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5168869/
https://ncbi.nlm.nih.gov/pubmed/27998294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-1097-0
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