SOX2 and SOX2-MYC Reprogramming Process of Fibroblasts to the Neural Stem Cells Compromised by Senescence

Tumorigenic potential of induced pluripotent stem cells (iPSCs) infiltrating population of induced neural stem cells (iNSCs) generated from iPSCs may limit their medical applications. To overcome such a difficulty, direct reprogramming of adult somatic cells into iNSCs was proposed. The aim of this...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Winiecka-Klimek, Marta, Smolarz, Maciej, Walczak, Maciej P., Zieba, Jolanta, Hulas-Bigoszewska, Krystyna, Kmieciak, Blazej, Piaskowski, Sylwester, Rieske, Piotr, Grzela, Dawid P., Stoczynska-Fidelus, Ewelina
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633175/
https://ncbi.nlm.nih.gov/pubmed/26535892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141688
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