Osteopontin Blockade Attenuates Renal Injury after Ischemia Reperfusion by Inhibiting NK Cell Infiltration

Renal ischemia-reperfusion (RIR) injury is a common occurrence after major surgery and shock, leading to acute kidney injury (AKI). Osteopontin (OPN) is a secreted glycoprotein that acts as a proinflammatory cytokine and activator of T lymphocytes. We hypothesized that blockade of OPN reduces the se...

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Udgivet i:Shock
Main Authors: Cen, Cindy, Aziz, Monowar, Yang, Weng-Lang, Nicastro, Jeffrey M., Coppa, Gene F., Wang, Ping
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5167622/
https://ncbi.nlm.nih.gov/pubmed/27504800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000000721
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