The Ku Protein Complex Interacts with YY1, Is Up-Regulated in Human Heart Failure, and Represses α Myosin Heavy-Chain Gene Expression

Human heart failure is accompanied by repression of genes such as α myosin heavy chain (αMyHC) and SERCA2A and the induction of fetal genes such as βMyHC and atrial natriuretic factor. It seems likely that changes in MyHC isoforms contribute to the poor contractility seen in heart failure, because s...

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Autors principals: Sucharov, Carmen C., Helmke, Steve M., Langer, Stephen J., Perryman, M. Benjamin, Bristow, Michael, Leinwand, Leslie
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Transcriptional Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC516749/
https://ncbi.nlm.nih.gov/pubmed/15367688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.19.8705-8715.2004
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