The Ku Protein Complex Interacts with YY1, Is Up-Regulated in Human Heart Failure, and Represses α Myosin Heavy-Chain Gene Expression

Human heart failure is accompanied by repression of genes such as α myosin heavy chain (αMyHC) and SERCA2A and the induction of fetal genes such as βMyHC and atrial natriuretic factor. It seems likely that changes in MyHC isoforms contribute to the poor contractility seen in heart failure, because s...

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Bibliografiske detaljer
Udgivet i:Mol Cell Biol
Main Authors: Sucharov, Carmen C., Helmke, Steve M., Langer, Stephen J., Perryman, M. Benjamin, Bristow, Michael, Leinwand, Leslie
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2004
Fag:
Transcriptional Regulation
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC516749/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15367688/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.19.8705-8715.2004
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