Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production

Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by multiorgan inflammation induced by autoantibodies. Early growth response gene 2 (Egr2), a transcription factor essential for T-cell anergy induction, controls systemic autoimmunity in mice and humans. We have pr...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Morita, Kaoru, Okamura, Tomohisa, Inoue, Mariko, Komai, Toshihiko, Teruya, Shuzo, Iwasaki, Yukiko, Sumitomo, Shuji, Shoda, Hirofumi, Yamamoto, Kazuhiko, Fujio, Keishi
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5167141/
https://ncbi.nlm.nih.gov/pubmed/27911796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611286114
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