TGF-β3-expressing CD4(+)CD25(−)LAG3(+) regulatory T cells control humoral immune responses

Autoantibodies induce various autoimmune diseases, including systemic lupus erythematosus (SLE). We previously described that CD4(+)CD25(−)LAG3(+) regulatory T cells (LAG3(+) Treg) are regulated by Egr2, a zinc-finger transcription factor required for the induction of T-cell anergy. We herein demons...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Okamura, Tomohisa, Sumitomo, Shuji, Morita, Kaoru, Iwasaki, Yukiko, Inoue, Mariko, Nakachi, Shinichiro, Komai, Toshihiko, Shoda, Hirofumi, Miyazaki, Jun-ichi, Fujio, Keishi, Yamamoto, Kazuhiko
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346620/
https://ncbi.nlm.nih.gov/pubmed/25695838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7329
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