Anticancer Effects of a New SIRT Inhibitor, MHY2256, against Human Breast Cancer MCF-7 Cells via Regulation of MDM2-p53 Binding

The sirtuins (SIRTs), a family of NAD(+)-dependent class III histone deacetylase, are involved in various biological processes including cell survival, division, senescence, and metabolism via activation of the stress-response pathway. Recently, inhibition of SIRTs has been considered a promising an...

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Gepubliceerd in:Int J Biol Sci
Hoofdauteurs: Park, Eun Young, Woo, Youngwoo, Kim, Seong Jin, Kim, Do Hyun, Lee, Eui Kyung, De, Umasankar, Kim, Kyeong Seok, Lee, Jaewon, Jung, Jee H., Ha, Ki-Tae, Choi, Wahn Soo, Kim, In Su, Lee, Byung Mu, Yoon, Sungpil, Moon, Hyung Ryong, Kim, Hyung Sik
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Ivyspring International Publisher 2016
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5166496/
https://ncbi.nlm.nih.gov/pubmed/27994519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.13833
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