Defective dendritic cell migration and activation of adaptive immunity in PI3Kγ-deficient mice

Gene-targeted mice were used to evaluate the role of the gamma isoform of phosphoinositide 3-kinase (PI3Kγ) in dendritic cell (DC) migration and induction of specific T-cell-mediated immune responses. DC obtained from PI3Kγ−/− mice showed a reduced ability to respond to chemokines in vitro and ex vi...

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Vydáno v:EMBO J
Hlavní autoři: Del Prete, Annalisa, Vermi, William, Dander, Erica, Otero, Karel, Barberis, Laura, Luini, Walter, Bernasconi, Sergio, Sironi, Marina, Santoro, Amerigo, Garlanda, Cecilia, Facchetti, Fabio, Wymann, Matthias P, Vecchi, Annunciata, Hirsch, Emilio, Mantovani, Alberto, Sozzani, Silvano
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2004
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Article
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC516633/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15318168/
https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600361
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