Defective dendritic cell migration and activation of adaptive immunity in PI3Kγ-deficient mice

Gene-targeted mice were used to evaluate the role of the gamma isoform of phosphoinositide 3-kinase (PI3Kγ) in dendritic cell (DC) migration and induction of specific T-cell-mediated immune responses. DC obtained from PI3Kγ−/− mice showed a reduced ability to respond to chemokines in vitro and ex vi...

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Main Authors: Del Prete, Annalisa, Vermi, William, Dander, Erica, Otero, Karel, Barberis, Laura, Luini, Walter, Bernasconi, Sergio, Sironi, Marina, Santoro, Amerigo, Garlanda, Cecilia, Facchetti, Fabio, Wymann, Matthias P, Vecchi, Annunciata, Hirsch, Emilio, Mantovani, Alberto, Sozzani, Silvano
Format: Artigo
Language:Inglês
Published: 2004
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC516633/
https://ncbi.nlm.nih.gov/pubmed/15318168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600361
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