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Defective dendritic cell migration and activation of adaptive immunity in PI3Kγ-deficient mice
Gene-targeted mice were used to evaluate the role of the gamma isoform of phosphoinositide 3-kinase (PI3Kγ) in dendritic cell (DC) migration and induction of specific T-cell-mediated immune responses. DC obtained from PI3Kγ−/− mice showed a reduced ability to respond to chemokines in vitro and ex vi...
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| Autori principali: | , , , , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC516633/ https://ncbi.nlm.nih.gov/pubmed/15318168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600361 |
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