A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition

T cells generally recognize peptide antigens bound to MHC proteins through contacts with residues found within or immediately flanking the seven- to nine-residue sequence accommodated in the MHC peptide-binding groove. However, some T cells require peptide residues outside this region for activation...

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Detalles Bibliográficos
Main Authors: Zavala-Ruiz, Zarixia, Strug, Iwona, Walker, Bruce D., Norris, Philip J., Stern, Lawrence J.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC516560/
https://ncbi.nlm.nih.gov/pubmed/15331779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403371101
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