Distinct Patterns of Tryptophan Maintenance in Tissues during Kynurenine Pathway Activation in Simian Immunodeficiency Virus-Infected Macaques

Induction of the kynurenine pathway (KP) of tryptophan (TRP) catabolism has been proposed to contribute to T cell dysfunction during human/simian immunodeficiency virus (SIV) infection via depletion of local TRP levels and production of immunomodulatory KP metabolites. However, while changes in TRP...

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Udgivet i:Front Immunol
Main Authors: Drewes, Julia L., Croteau, Joshua D., Shirk, Erin N., Engle, Elizabeth L., Zink, M. C., Graham, David R.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2016
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5165277/
https://ncbi.nlm.nih.gov/pubmed/28066416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00605
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