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Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled
The activation-induced cytidine deaminase (AID) is required for somatic hypermutation (SHM) and class-switch recombination of Ig genes. It has been shown that in vitro, AID protein deaminates C in single-stranded DNA or the coding-strand DNA that is being transcribed but not in double-stranded DNA....
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC516507/ https://ncbi.nlm.nih.gov/pubmed/15328407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404974101 |
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