Regulation of autoantibody activity by the IL-23–T(H)17 axis determines the onset of autoimmune disease

The checkpoints and mechanisms that contribute to autoantibody-driven disease are as yet incompletely understood. Here we identified the axis of interleukin 23 (IL-23) and the T(H)17 subset of helper T cells as a decisive factor that controlled the intrinsic inflammatory activity of autoantibodies a...

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Publicado no:Nat Immunol
Main Authors: Pfeifle, René, Rothe, Tobias, Ipseiz, Natacha, Scherer, Hans U, Culemann, Stephan, Harre, Ulrike, Ackermann, Jochen A, Seefried, Martina, Kleyer, Arnd, Uderhardt, Stefan, Haugg, Benjamin, Hueber, Axel J, Daum, Patrick, Heidkamp, Gordon F, Ge, Changrong, Böhm, Sybille, Lux, Anja, Schuh, Wolfgang, Magorivska, Iryna, Nandakumar, Kutty S, Lönnblom, Erik, Becker, Christoph, Dudziak, Diana, Wuhrer, Manfred, Rombouts, Yoann, Koeleman, Carolien A, Toes, René, Winkler, Thomas H, Holmdahl, Rikard, Herrmann, Martin, Blüml, Stephan, Nimmerjahn, Falk, Schett, Georg, Krönke, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5164937/
https://ncbi.nlm.nih.gov/pubmed/27820809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3579
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