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Genome-wide genetic screening with chemically-mutagenized haploid embryonic stem cells
In model organisms, classical genetic screening via random mutagenesis provides key insights into the molecular bases of genetic interactions, helping defining synthetic-lethality, synthetic-viability and drug-resistance mechanisms. The limited genetic tractability of diploid mammalian cells, howeve...
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| Vydáno v: | Nat Chem Biol |
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| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5164930/ https://ncbi.nlm.nih.gov/pubmed/27820796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2226 |
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