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Identification of Small Molecule PHD2 Zinc Finger Inhibitors that Activate Hypoxia Inducible Factor

The Prolyl Hydroxylase Domain protein (PHD):Hypoxia Inducible Factor (HIF) pathway is the main pathway by which changes in oxygen concentration are transduced to changes in gene expression. In mammals, there are three PHD paralogues, and PHD2 has emerged as a particularly critical one for regulating...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Chembiochem
Egile Nagusiak: Arsenault, Patrick R., Song, Daisheng, Bergkamp, Marian, Ravaschiere, Andrew M., Navalsky, Bradleigh E., Lieberman, Paul M., Lee, Frank S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5163474/
https://ncbi.nlm.nih.gov/pubmed/27770548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201600493
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