Identification of Small Molecule PHD2 Zinc Finger Inhibitors that Activate Hypoxia Inducible Factor

The Prolyl Hydroxylase Domain protein (PHD):Hypoxia Inducible Factor (HIF) pathway is the main pathway by which changes in oxygen concentration are transduced to changes in gene expression. In mammals, there are three PHD paralogues, and PHD2 has emerged as a particularly critical one for regulating...

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Detalhes bibliográficos
Publicado no:Chembiochem
Main Authors: Arsenault, Patrick R., Song, Daisheng, Bergkamp, Marian, Ravaschiere, Andrew M., Navalsky, Bradleigh E., Lieberman, Paul M., Lee, Frank S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5163474/
https://ncbi.nlm.nih.gov/pubmed/27770548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201600493
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