A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA–induced IL-12 production and Th cell differentiation

A serine/threonine protein kinase, Cot/Tpl2, is indispensable for extracellular signal–regulated kinase (ERK) activation and production of TNF-α and PGE(2) in LPS-stimulated macrophages. We show here that Cot/Tpl2 is also activated by other Toll-like receptor (TLR) ligands. Bacterial DNA rich in the...

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Bibliografiske detaljer
Main Authors: Sugimoto, Kenji, Ohata, Mutsuhiro, Miyoshi, Jun, Ishizaki, Hiroyoshi, Tsuboi, Naotake, Masuda, Akio, Yoshikai, Yasunobu, Takamoto, Masaya, Sugane, Kazuo, Matsuo, Seiichi, Shimada, Yasuhiro, Matsuguchi, Tetsuya
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2004
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC516257/
https://ncbi.nlm.nih.gov/pubmed/15372110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420014
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