Sterile Inflammation in Acetaminophen-induced Liver Injury Is Mediated by Cot/tpl2

Cot/tpl2 (MAP3K8) activates MKK1/2-Erk1/2 following stimulation of the Toll-like/IL-1 receptor superfamily. Here, we investigated the role of Cot/tpl2 in sterile inflammation and drug-induced liver toxicity. Cot/tpl2 KO mice exhibited reduced hepatic injury after acetaminophen challenge, as evidence...

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Detalhes bibliográficos
Main Authors: Sanz-Garcia, Carlos, Ferrer-Mayorga, Gemma, González-Rodríguez, Águeda, Valverde, Ángela M., Martín-Duce, Antonio, Velasco-Martín, Juan P., Regadera, Javier, Fernández, Margarita, Alemany, Susana
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663553/
https://ncbi.nlm.nih.gov/pubmed/23572518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.439547
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