Sterile Inflammation in Acetaminophen-induced Liver Injury Is Mediated by Cot/tpl2

Cot/tpl2 (MAP3K8) activates MKK1/2-Erk1/2 following stimulation of the Toll-like/IL-1 receptor superfamily. Here, we investigated the role of Cot/tpl2 in sterile inflammation and drug-induced liver toxicity. Cot/tpl2 KO mice exhibited reduced hepatic injury after acetaminophen challenge, as evidence...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sanz-Garcia, Carlos, Ferrer-Mayorga, Gemma, González-Rodríguez, Águeda, Valverde, Ángela M., Martín-Duce, Antonio, Velasco-Martín, Juan P., Regadera, Javier, Fernández, Margarita, Alemany, Susana
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2013
Pynciau:
Molecular Bases of Disease
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663553/
https://ncbi.nlm.nih.gov/pubmed/23572518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.439547
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg