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Hypocretin Neurotransmission within the Central Amygdala Mediates Escalated Cocaine Self-Administration and Stress-induced Reinstatement in Rats

BACKGROUND: Cocaine addiction is characterized by patterns of compulsive drug-taking, including preoccupation with obtaining cocaine and loss of control over drug intake. The lateral hypothalamic hypocretin/orexin (HCRT) system has been implicated in drug-taking and the reinstatement of drug-seeking...

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Publicado en:Biol Psychiatry
Main Authors: Schmeichel, Brooke E., Herman, Melissa A., Roberto, Marisa, Koob, George F.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161745/
https://ncbi.nlm.nih.gov/pubmed/27567312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2016.06.010
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