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Structural basis for the antifolding activity of a molecular chaperone

Molecular chaperones act on non-native proteins in the cell to prevent their aggregation, premature folding or misfolding. Different chaperones often exert distinct effects, such as acceleration or delay of folding, on client proteins via mechanisms that are poorly understood. Here we report the sol...

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Detalles Bibliográficos
Publicado en:Nature
Main Authors: Huang, Chengdong, Rossi, Paolo, Saio, Tomohide, Kalodimos, Charalampos G.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161705/
https://ncbi.nlm.nih.gov/pubmed/27501151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature18965
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