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Ubiquitin Utilizes an Acidic Surface Patch to Alter Chromatin Structure
Ubiquitylation of histone H2B, associated with gene activation, leads to chromatin decompaction through an unknown mechanism. We used a hydrogen-deuterium exchange strategy coupled with nuclear magnetic resonance spectroscopy to map the ubiquitin surface responsible for its structural effects on chr...
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| Veröffentlicht in: | Nat Chem Biol |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5161692/ https://ncbi.nlm.nih.gov/pubmed/27870837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2235 |
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