Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome

Human cytomegalovirus (hCMV) immediate early 1 (IE1) protein associates with condensed chromatin of the host cell during mitosis. We have determined the structure of the chromatin-tethering domain (CTD) of IE1 bound to the nucleosome core particle, and discovered that the specific interaction betwee...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:eLife
Main Authors: Fang, Qianglin, Chen, Ping, Wang, Mingzhu, Fang, Junnan, Yang, Na, Li, Guohong, Xu, Rui-Ming
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2016
Teme:
Biochemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764553/
https://ncbi.nlm.nih.gov/pubmed/26812545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11911
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