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The role of the nucleosome acidic patch in modulating higher order chromatin structure
Higher order folding of chromatin fibre is mediated by interactions of the histone H4 N-terminal tail domains with neighbouring nucleosomes. Mechanistically, the H4 tails of one nucleosome bind to the acidic patch region on the surface of adjacent nucleosomes, causing fibre compaction. The functiona...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Royal Society
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3627075/ https://ncbi.nlm.nih.gov/pubmed/23446052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2012.1022 |
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