Resatorvid-based Pharmacological Antagonism of Cutaneous TLR4 Blocks UV-induced NF-κB and AP-1 Signaling in Keratinocytes and Mouse Skin

Cutaneous exposure to solar ultraviolet (UV) radiation is a major causative factor in skin carcinogenesis, and improved molecular strategies for efficacious chemoprevention of non-melanoma skin cancer (NMSC) are urgently needed. Toll-like receptor 4 (TLR4) signaling has been shown to drive skin infl...

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Udgivet i:Photochem Photobiol
Main Authors: Janda, Jaroslav, Burkett, Nichole, Blohm-Mangone, Karen, Huang, Vivian, Curiel-Lewandrowski, Clara, Alberts, David S., Petricoin, Emanuel F., Calvert, Valerie S., Einspahr, Janine, Dong, Zigang, Bode, Ann M., Wondrak, Georg T., Dickinson, Sally E.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161657/
https://ncbi.nlm.nih.gov/pubmed/27859308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/php.12659
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