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Modulating carbohydrate-protein interactions through glycoengineering of monoclonal antibodies to impact cancer physiology

Diverse glycans on proteins help impact cell and organism physiology along with drug activity. Since many protein-based biotherapeutics are glycosylated and these glycans have biological activity, there is a desire to engineer glycosylation for recombinant protein-based biotherapeutics. Engineered g...

詳細記述

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書誌詳細
出版年:Curr Opin Struct Biol
主要な著者: Chiang, Austin W.T., Li, Shangzhong, Spahn, Philipp N., Richelle, Anne, Kuo, Chih-Chung, Samoudi, Mojtaba, Lewis, Nathan E.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161599/
https://ncbi.nlm.nih.gov/pubmed/27639240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2016.08.008
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