Discovery of Novel Small Molecule Inhibitors of VEGF Expression in Tumor Cells Using a Cell-Based High Throughput Screening Platform

Current anti-VEGF (Vascular Endothelial Growth Factor A) therapies to treat various cancers indiscriminately block VEGF function in the patient resulting in the global loss of VEGF signaling which has been linked to dose-limiting toxicities as well as treatment failures due to acquired resistance. A...

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Publicado no:PLoS One
Main Authors: Cao, Liangxian, Weetall, Marla, Bombard, Jenelle, Qi, Hongyan, Arasu, Tamil, Lennox, William, Hedrick, Jean, Sheedy, Josephine, Risher, Nicole, Brooks, Peter C., Trifillis, Panayiota, Trotta, Christopher, Moon, Young-Choon, Babiak, John, Almstead, Neil G., Colacino, Joseph M., Davis, Thomas W., Peltz, Stuart W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161367/
https://ncbi.nlm.nih.gov/pubmed/27992500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168366
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