Selectivity and affinity of triplex-forming oligonucleotides containing 2′-aminoethoxy-5-(3-aminoprop-1-ynyl)uridine for recognizing AT base pairs in duplex DNA

We have used DNase I footprinting, fluorescence and ultraviolet (UV) melting experiments and circular dichroism to demonstrate that, in the parallel triplex binding motif, 2′-aminoethoxy-5-(3-aminoprop-1-ynyl)uridine (bis-amino-U, BAU) has very high affinity for AT relative to all other Watson–Crick...

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Detaylı Bibliyografya
Asıl Yazarlar: Osborne, Sadie D., Powers, Vicki E. C., Rusling, David A., Lack, Oliver, Fox, Keith R., Brown, Tom
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2004
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC516051/
https://ncbi.nlm.nih.gov/pubmed/15317869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh776
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